LL202抑制结肠炎的作用研究文献综述

 2023-02-23 11:02

综述

细胞因子在结肠炎中的作用研究综述

摘要

溃疡性结肠炎(ulcerative colitis，UC) 是一种原因不明的慢性非特异性炎症性肠病(inflammatory bowel disease， IBD)，流行病学调查结果表明，其发病率在世界范围内呈逐年升高的趋势，目前认为UC 与感染、环境、免疫以及遗传等多种因素有关，但具体机制尚不清楚，有报道免疫调节机制中炎症细胞因子在UC 的发病中可能发挥重要作用。细胞因子是由细胞分泌的具有生物活性的小分子蛋白质的总称，当受到致病菌刺激时，肠上皮细胞能够持续表达和分泌多种细胞因子。不同的细胞因子具有不同的生物学作用，对于UC患者，细胞因子作为炎症介质能够介导结肠黏膜的病理性损伤。本文就细胞因子在UC中的作用做一综述。

关键词 结肠炎；细胞因子；炎症

Abstract

Ulcerative colitis（UC） is a chronic inflammatory bowel disease. Epidemiological researches showed the morbidity rate of UC is rising year-by-year worldwidly. The etiology of UC is complicated and relevant with various factors, including infection, environment, immune, and heredity, but the concrete mechanism still remains unknown. Recently, more and more studies are showing that inflammatory cytokines play a pivotal role in the process of UC. Cytokines are micro-molecular proteins, which are secreted by cells and possess many different bioactivities. Enterocytes are able to secrete various kinds of cytokines sustainedly when stimulated by pathogenic bacteria. Different cytokines have different biological functions. For UC patients, cytokines function as inflammatory mediator that mediate pathological injury of colonic mucosa. This essay is going to make a review about the vital role of cytokines in the development of UC.

Key words Cytokine; Ulcerative colitis; Inflammation

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